One primary problem in shape optimization of structures is making a robust link between design model (geometric description) and analysis model. This paper investigates the potential of Isogeometric Analysis (IGA) for solving this problem. The generic framework of shape optimization of structures is presented based on Isogeometric analysis. By discretization of domain via NURBS functions, the analysis model will precisely demonstrate the geometry of structure. In this study Particle Swarm Optimization (PSO) is used for Isogeometric shape optimization. The option of selecting the position and weight of control points as design variables, needless to sensitivity analysis relationships, is the superiority of the proposed method over gradient-based methods. The other advantages of this method are its straightforward implementation and acceptable accuracy. The numerical examples verify the authenticity of this method.